the polg gene polymorphism in iranian varicocele-associated infertility patients

The POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients

Objective(s) Varicocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients.    Materials and Methods We determined the POLG CAG repe...

The POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients

OBJECTIVES Varicocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients. MATERIALS AND METHODS We determined the POLG CAG repeat len...

Modified subinguinal varicocelectomy for painful varicocele and varicocele-associated infertility.

BACKGROUND Patients with varicocele comprise 15% of males in general population. Varicocele is considered the most cost-effectively treatable cause of male infertility. We introduce a modification in technique of subinguinal varicocelectomy and review the outcome of 58 patients from July 2000 to July 2002. METHODS Four out of the 58 cases had both pain and infertility. For the 31 infertility ...

The 763C>G Polymorphism of The Secretory PLA2IIa Gene Is Associated with Endometriosis in Iranian Women

New single nucleotide polymorphism G5508A in the SEPT12 gene may be associated with idiopathic male infertility in Iranian men

BACKGROUND Male infertility is a multifactorial disorder, which affects approximately 10% of couples at childbearing age with substantial clinical and social impact. Genetic factors are associated with the susceptibility to spermatogenic impairment in humans. Recently, SEPT12 is reported as a critical gene for spermatogenesis. This gene encodes a testis specific member of Septin proteins, a fam...

Single nucleotide polymorphisms of the heat shock protein 90 gene in varicocele-associated infertility.

PURPOSE Varicoceles are associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. Spermatogenesis might be affected by increased scrotal temperature, such as that caused by varicocele. HSP90 is a molecular chaperone expressed in germ cells and is related to spermatogenesis, motility, and...